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// File: TS98.h
// Created by: Julien Dutheil
// Created on: Sat Aug 19 11:37 2006
//
/*
Copyright or © or Copr. CNRS, (November 16, 2004)
This software is a computer program whose purpose is to provide classes
for phylogenetic data analysis.
This software is governed by the CeCILL license under French law and
abiding by the rules of distribution of free software. You can use,
modify and/ or redistribute the software under the terms of the CeCILL
license as circulated by CEA, CNRS and INRIA at the following URL
"http://www.cecill.info".
As a counterpart to the access to the source code and rights to copy,
modify and redistribute granted by the license, users are provided only
with a limited warranty and the software's author, the holder of the
economic rights, and the successive licensors have only limited
liability.
In this respect, the user's attention is drawn to the risks associated
with loading, using, modifying and/or developing or reproducing the
software by the user in light of its specific status of free software,
that may mean that it is complicated to manipulate, and that also
therefore means that it is reserved for developers and experienced
professionals having in-depth computer knowledge. Users are therefore
encouraged to load and test the software's suitability as regards their
requirements in conditions enabling the security of their systems and/or
data to be ensured and, more generally, to use and operate it in the
same conditions as regards security.
The fact that you are presently reading this means that you have had
knowledge of the CeCILL license and that you accept its terms.
*/
#ifndef _TS98_H_
#define _TS98_H_
#include "MarkovModulatedSubstitutionModel.h"
//From NumCalc:
#include <Bpp/Numeric/Prob/DiscreteDistribution.h>
#include <Bpp/Numeric/Parameter.h>
namespace bpp
{
/**
* @brief Tuffley and Steel's 1998 covarion model.
*
* This model is a subclass of the so-called Markov-modulated substitution models,
* with a rate matrix
* @f[
* G = \begin{pmatrix}
* -s_1 & s_1\\
* s_2 & -s_2
* \end{pmatrix}
* @f]
* and
* @f[
* D_R = \begin{pmatrix}
* 0 & 0\\
* 0 & \dfrac{s_1+s_2}{s_1}
* \end{pmatrix}.
* @f]
* This model was originally designed for nucleotides sequences, but it can be used with other alphabets.
*
* @see MarkovModulatedSubstitutionModel
*
* Tuffley C. and Steel M. A., Modelling the covarion hypothesis of nucleotide substitution (1998),
* _Math. Biosci._, 147:63-91.
*/
class TS98:
public MarkovModulatedSubstitutionModel
{
public:
/**
* @brief Build a new TS98 substitution model.
*
* @param model The substitution model to use. May be of any alphabet type.
* @param s1 First rate parameter.
* @param s2 Second rate parameter.
* @param normalizeRateChanges Tell if the rate transition matrix should be normalized.
*/
TS98(ReversibleSubstitutionModel * model, double s1 = 1., double s2 = 1., bool normalizeRateChanges = false):
MarkovModulatedSubstitutionModel(model, normalizeRateChanges, "TS98.")
{
nbRates_ = 2;
ratesExchangeability_.resize(2, 2);
rates_.resize(2, 2);
ratesFreq_.resize(2);
addParameter_(new Parameter("TS98.s1", s1, &Parameter::R_PLUS_STAR));
addParameter_(new Parameter("TS98.s2", s2, &Parameter::R_PLUS_STAR));
updateRatesModel();
updateMatrices();
}
virtual ~TS98() {}
#ifndef NO_VIRTUAL_COV
TS98*
#else
Clonable*
#endif
clone() const { return new TS98(*this); }
public:
std::string getName() const { return "TS98"; }
double getRate() const { return 1.;}
void setRate(double rate) {};
void addRateParameter() {};
protected:
void updateRatesModel()
{
double s1 = getParameterValue("s1");
double s2 = getParameterValue("s2");
ratesFreq_[0] = s2/(s1+s2);
ratesFreq_[1] = s1/(s1+s2);
rates_(1,1) = (s1+s2)/s1;
ratesExchangeability_(0,1) = ratesExchangeability_(1,0) = s1+s2;
ratesExchangeability_(0,0) = -s1*(s1+s2)/s2;
ratesExchangeability_(1,1) = -s2*(s1+s2)/s1;
}
};
} //end of namespace bpp.
#endif // _TS98_H_
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